| Player | Pos. | High School | College |
|---|---|---|---|
| 1. Marcus Lattimore | RB | Byrnes | USC |
| 2. Kelcy Quarles | DL | Greenwood | USC |
| 3. DeAndre Hopkins | ATH | Central | Clemson |
| 4. Brandon Willis | DE | Byrnes | North Carolina |
| 5. A.J. Cann | OL | Bamberg-Erhardt | USC |
| 6. Martavis Bryant | WR | T.L. Hanna | Clemson |
| 7. John Fulton | DB | Manning | Alabama |
| 8. Dexter Morant | DE | Manning | Georgia |
| 9. Eric Mack | OL | Calhoun Co. | Auburn |
| 10. Justin Parker | LB | Beaufort | Clemson |
| 11. Mustafa Greene | RB | Irmo | N.C. State |
| 12. Corey Miller | DE | Byrnes | Tennessee |
| 13. Victor Hampton | DB | Darlington | USC |
| 14. Nick Jones | WR | Byrnes | USC |
| 15. Joe Craig | ATH | Gaffney | Clemson |
| 16. Brice Laughlin | DT | Summerville | Kentucky |
| 17. Marques Pair | OL | Sumter | Tennessee |
| 18. Brandon Golson | LB | Calhoun Co. | USC |
| 19. Kalon Davis | OL | Chester | Clemson |
| 20. Jerrell Priester | ATH | Allendale-Fairfax | Kentucky |
| 21. Bashaud Breeland | ATH | Allendale-Fairfax | Clemson |
| 22. Ricky Chaney | LB | Beaufort | Clemson |
| 23. Thomas Teal | DT | Marlboro Co. | N.C. State |
| 24. Dylan Thompson | QB | Boiling Springs | USC |
| 25. Farrington Huguenin | DE | Dreher | Kentucky |
