BOSTON — The White Sox lost in walk-off fashion for the second consecutive night at Fenway Park on Thursday.
After Conor Gillaspie's third home run in three games tied it in the ninth inning, reliever Ronald Belisario gave up the winning walk-off single to pinch-hitter Mike Carp in a 4-3 loss to the Red Sox in 10 innings.
The White Sox totaled a season-high 16 strikeouts, including 12 against Red Sox starter Jon Lester, and went 0-for-10 with runners in scoring position. White Sox left-hander Jose Quintana allowed three runs on two hits, walked two and struck out seven.
The White Sox, who dropped to 44-49, head to Cleveland for three games against the Indians before the All-Star break.
Belisario walked Daniel Nava, and after a sacrifice bunt, he intentionally walked Stephen Drew. That brought up Carp, whose single to left field won it.
The White Sox took an early lead in each of the first three games against the Red Sox this week, and Jose Abreu made it happen again Thursday.
Abreu hit an RBI double off Red Sox left-hander Jon Lester to drive in Adam Eaton for a 1-0 White Sox lead in the first inning.
White Sox left-hander Jose Quintana held the Red Sox scoreless through five perfect innings before he surrendered the lead in the sixth.
He walked the first two batters he faced and then gave up an RBI single to Jackie Bradley Jr. After Quintana recorded two outs, Red Sox designated hitter David Ortiz hit a two-run double to give the Red Sox a 3-1 lead.
The White Sox won a big challenge to start the ninth when Alexei Ramirez was called out at first on a close play. The call was overturned, giving the White Sox a runner on first with no outs. Conor Gillaspie then hit a pinch-hit, two-run homer off Red Sox closer Koji Uehara to tie the game at 3-3 in the ninth.
It was Gillaspie's third homer in three days at Fenway Park. All four of his homers this season have come in July.
The combination of relievers Daniel Webb, Eric Surkamp and Belisario shut down the Red Sox's 2-3-4 hitters in the ninth to send the game to extra innings.
The Sox were trying to recover from the latest bullpen meltdown on Wednesday, when they were left wondering once again which relievers can be counted on in high-leverage situations.
White Sox relievers Jake Petricka and Javy Guerra gave up four runs while trying to get the final four outs of a 5-4 loss to the Red Sox on Wednesday night at Fenway Park. Petricka had been one of the most successful White Sox relievers in recent weeks.
In July, White Sox manager Robin Ventura still is having to find the right fit for his relievers, many of them relatively inexperienced coming into this season.
"They're going to get used to (big spots) because they're the guys in the bullpen," Ventura said. "We can't just add people to put out there. So they're going to get experience and that's part of it. ... You're trying to find a way to make it work and put guys in good situations, situations they can be successful in. Whether it happens or not, it doesn't guarantee it, but these are the guys we have and this is who we're pitching."
As he did Wednesday night, Ventura defended his decision to pull left-hander Chris Sale after 7 2/3 innings and 107 pitches and have Petricka face Dustin Pedroia, who hit an RBI single to start a rally.
"If you're going to give him Pedroia, you're going to give him (David Ortiz), and all of a sudden he starts getting extended to a point I wasn't comfortable," Ventura said. "We kind of figured right around 110 would be his number. Also it was the fourth time around (the lineup). The fourth time around hasn't really been a good thing for him."