The already dinged-up backfield took two more hits as P.J. Pope (hamstring) and Selvin Young (neck) were added to the long list of injured tailbacks.
Broncos coach Mike Shanahan said both are expected to be placed on injured reserve. The team has lost seven tailbacks this season.
Denver is expected to bolster its depth at tailback by activating former South Carolina player Cory Boyd off the practice squad and signing Alex Haynes, who was waived by the Broncos on Nov. 22.
Pope became the sixth tailback to start in the Broncos' battered backfield Sunday against Buffalo but went to the sideline in the first quarter with a torn left hamstring. He finished with six carries for 44 yards. He's expected to be out six to eight weeks.
Young picked up the slack for Pope before leaving with a pinched nerve in his neck late in the third quarter. An MRI on Monday revealed Young had a ruptured disk
The injuries to Pope and Young left Tatum Bell as the only healthy running back. Bell carried the ball five times for 20 yards.
The Broncos released Boyd last week but re-signed him the Broncos' practice squad.
Boyd is a rookie who originally signed with the Broncos practice squad Nov. 4. He was promoted to the active roster Dec. 9 but was deactivated at Carolina after failing to impress coaches enough with his blitz pickup.
Boyd was a seventh-round draft pick by Tampa Bay out of South Carolina but was waived/injured by the Buccaneers on July 26.