Connor Shaw threw for 219 yards and accounted for four touchdowns, and No. 14 South Carolina dominated Arkansas in a 52-7 win.
Mike Davis added 128 yards rushing on 19 carries for the Gamecocks (5-1, 3-1 Southeastern Conference), who won their fourth straight game after a loss to Georgia on Sept. 7.
All-American defensive end Jadeveon Clowney returned after missing last week's game against Kentucky and had one tackle for South Carolina, which outgained the Razorbacks 537-248.
The loss is the fourth straight for Arkansas (3-4, 0-3), matching first-year coach Bret Bielema's longest losing streak of his career.
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It was also his most lopsided loss as a coach. The Razorbacks are 0-3 in the SEC for the first time since 2007.