Fort Jackson Boulevard reopened Thursday, clearing a major passageway off Interstate 77 near the Cross Hill Market and Fort Jackson Army base in Columbia.
Flora Drive also reopened in Northeast Richland on Thursday.
Major thoroughfares Decker Boulevard and Percival Road opened in Richland County earlier this week.
Still, about 60 roads remain closed in the county, down from peak of 133.
In Lexington County, 11 roads remain closed: Barnwell Road, Devils Backbone Road, Durham Drive, Drawdebil Road, Old Ramblin Road, Ottawa Trail/Natchez Street, Sandlewood Drive, Taylor Street, Wilton Road, Windy Road and Woodberry Road.