South Carolina Department of Public Safety officials said there were seven road deaths reported over the weekend.
Officials said all four deaths occurred on U.S. routes, S.C. roads and secondary roads.
In two of the deaths, officials said a seat belt was used, while one other did not use a seat belt. The other person killed was a pedestrian.
As of March 20, 180 people have died on state highways, compared to 200 highways deaths during the same time period in 2015. Of the 128 motor-vehicle occupants who have died in 2016, 68 were not wearing seat belts.
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Twenty-six pedestrians have been killed compared to 30 during the same time period in 2015. Seventeen motorcyclists have been killed compared to 17 in 2015. Five bicyclists have died in 2016 compared to four this time in 2015.