Camden opened Region 6-3A play with a 54-31 win at Crestwood on Friday.
The Bullgos wasted little time establishing control against the host Knight, racing to a 12-0 lead at the outset. Camden then went cold and Crestwood crept within 18-12 by halftime before the Bulldogs regained control after the break.
Josh Council led Camden with 21 points, and Tayler Workman added 12 to the cause.
The Bulldogs host Hartsville on Tuesday.
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In Region 5-3A, Brookland-Cayce (6-6, 3-1) took over sole possession of first place with a 72-62 win over Chapin, which has lost two in a row since getting off to a 2-0 start in region play, including an upset win over Lower Richland.
In other games, A.C. Flora and Dreher both picked up their first region wins.
Flora (3-9, 1-2) beat Midland Valley 59-56 with a balanced scoring attack featuring Desmond McDaniel (17 points), Matthew Howard (11) and Wildfred Roach (10). Quayshun Hawkins, who recently scored the 1,000th point of his career, led Dreher (9-7, 1-2) to a 54-38 rout of host Airport.
Tuesday’s games include Lower Richland at A.C. Flora, Brookland-Cayce at Midland Valley and Dreher at Chapin.
Fairfield Central, meanwhile, final gets into region play on Tuesday. The Griffins (4-9) make their Region 4-3A debut at Nation Ford, which recently dismissed veteran coach Donnie Holland.