A.C. Flora at Orangeburg-Wilkinson: Flora looks to get offense going in region opener.
Airport at Midland Valley: This game decided region title last year. This year, both teams head into region opener struggling.
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Batesburg-Leesville at Allendale-Fairfax: First meeting since 1996 between schools.
Ben Lippen at Laurence Manning: Ben Lippen looks to stop two-game slide after hot start.
Pick: Ben Lippen
Blythewood at Dutch Fork: Winner has the upper hand in Region 5-5A race.
Pick: Dutch Fork
Broome at Mid-Carolina: Mid-Carolina gets QB Corey Stone back, but faces tough challenge.
C.A. Johnson at Fox Creek: Both teams carry losing streaks into region opener.
Pick: Fox Creek
Cardinal Newman at Pinewood Prep: Cardinal Newman has lost three in a row after 2-0 start.
Pick: Pinewood Prep
Chapin at Dreher: Region opener for both should have plenty of points.
Columbia at Fairfield Central: Griffins will try to slow down Columbia RB Nate Miller.
Pick: Fairfield Central
Eau Claire at Saluda: Saluda Shrine Bowl back Malik Brooks is one of state’s best.
Gray Collegiate at Keenan: Gray Collegiate averaging 265 yards a game through the air.
Pick: Gray Collegiate
Hammond at Augusta Christian: Hammond has scored 54 points in each of past two games.
Lancaster at Westwood: Redhawks will try to bounce back after loss to No. 1 Dutch Fork.
Lee Central at North Central: At 5-0, Lee Central has been one of state’s surprise teams.
Pick: Lee Central
Lexington at River Bluff: First two games decided by four points. This one might not be that close.
Lower Richland at North Augusta: North Augusta is 0-2 against Midlands teams this year.
Pick: North Augusta
Lugoff-Elgin at Lakewood: Winless Lakewood averaging 6.5 points a game.
Pelion at Brookland-Cayce: B-C averaging 400 yards a game on offense.
Richland Northeast at York: Even without Tyquandre Davis, RNE running game is clicking.
Pick: Richland Northeast
Ridge View at South Pointe: Statement game for Ridge View against two-time defending state champs.
Pick: Ridge View
Swansea at Gilbert: Gilbert coach Chad Leaphart faces former team.
White Knoll at Irmo: White Knoll has won four in a row after opening loss.
Pick: White Knoll
Wilson Hall at Heathwood Hall: Heathwood has scored 14 points or less in past four games.
Pick: Wilson Hall
Woodruff at Newberry: Newberry finally gets to play home game in renovated stadium.
Last Week: 13-5