Clemson University

Clemson plays Duke today: Kick time, TV channel, injury report, score

Duke quarterback Darian Mensah (10) prepares to throw during the first half of Duke’s game against Georgia Tech at Wallace Wade Stadium in Durham, N.C., Saturday, Oct. 18, 2025.
Duke quarterback Darian Mensah (10) prepares to throw during the first half of Duke’s game against Georgia Tech at Wallace Wade Stadium in Durham, N.C., Saturday, Oct. 18, 2025. ehyman@newsobserver.com

After its second bye week of 2025, Clemson football is back at home again.

Here’s your gameday guide for the Tigers’ Saturday game against Duke.

Clemson vs. Duke game, TV info

Clemson vs. Duke Vegas odds

Clemson is favored by 3.5 points against Duke, per the VegasInsider.com consensus betting line as of Friday. That’s up from 2.5 points Thursday. Despite all of their struggles this season, the Tigers have still been favored in every game to date.

Clemson is 2-5 against the spread this season and 0-4 against the spread at home.

Weather forecast for Clemson, SC

After a rainy week in the area, the Clemson-Duke game should be a pleasant one. Weather.com’s 10-day forecast projects “party cloudy” skies for Saturday’s noon game, with a high of 64 degrees and a minimal chance of rain (7%).

Clemson running back Adam Randall
Clemson running back Adam Randall Tom Hauck Getty Images

Top storylines for the game

  • Clemson and Duke released their initial ACC availability reports Thursday night. Clemson, most notably, listed starting QB Cade Klubnik (ankle) as probable, putting him on track to play after a one-game absence. Offensive linemen Collin Sadler and Elyjah Thurmon (both of whom have started multiple games this season) are out. But usual starting left tackle Tristan Leigh is available after missing the SMU game. Duke’s most prominent new injury is to starting cornerback Kimari Robinson, who’s listed as questionable.
  • Clemson’s Memorial Stadium struggles are real. After an Oct. 18 home loss to SMU, the Tigers have now lost five straight home games to power conference teams for the first time since a six-game streak in 1970-71. Clemson lost at home to Louisville and South Carolina to end the 2024 season and has dropped home games to LSU, Syracuse and SMU this season. Their last home win against a P4 team came against Virginia — over a calendar year ago. That streak will be put to the test against a Duke team that hasn’t beaten Clemson in Death Valley since 1980. In 25 previous home games against Duke, Clemson is 20-4-1.
  • It’s crazy to think about the Duke game in context of bowl eligibility, but that’s where this Clemson team is. Sitting at 3-4 with five games left on their schedule, the preseason No. 4 Tigers must finish at least 3-2 to secure a 6-6 record and a spot in the college football postseason. Clemson’s home game against FCS Furman should be a blowout win. Past that, the Tigers are running out of opportunities. They must finish at least 2-2 against Duke (home), Florida State (home), No. 16 Louisville (road) and South Carolina (road). ESPN’s FPI gives Clemson a 66.1% chance of getting to six wins. Pro Football Focus gives the Tigers a 69% chance.
  • Duke’s passing offense will test Clemson. Starting quarterback and Tulane transfer Darian Mensah leads the country with 315.9 passing yards per game, and he has thrown 17 touchdowns against just two interceptions. The Blue Devils have averaged 36.5 points in four ACC games so far, and seven players have at least 100 receiving yards. On the other side, Clemson has the country’s No. 78 passing defense and just allowed SMU quarterback Kevin Jennings to pick them apart.
Clemson linebacker Sammy Brown
Clemson linebacker Sammy Brown Lance King Getty Images

Clemson vs. Duke players to watch

Clemson WR Tyler Brown: Brown’s production has dropped after he tallied 88 receiving yards across Clemson’s first two games (just 60 yards since). Could Bryant Wesco Jr.’s absence lead to more opportunities?

Clemson LB Sammy Brown: The sophomore has been arguably the most consistent player on the Tigers’ defense, with a team-high 50 tackles and 6.5 tackles for loss.

Duke RB Nate Sheppard: Mensah is a great passer, but don’t forget about his running back. Sheppard, a true freshman, has a team-high 497 rushing yards and 651 all-purpose yards and leads a one-two punch with Anderson Castle.

Duke DE Vincent Anthony Jr.: Team-high 10.5 tackles for loss and 6.5 sacks.

Clemson 2025 football schedule

Listed with known kickoff times and TV channels

Clemson 2025 football depth chart

As of Oct. 27

Offense

QB: Cade Klubnik (Christopher Vizzina)

RB: Adam Randall (David Eziomume OR Gideon Davidson)

Outside WR: T.J. Moore (Cole Turner)

Outside WR: Tristan Smith OR Cole Turner

Slot WR: Antonio Williams (Tyler Brown)

TE: Olsen Patt-Henry (Josh Sapp OR Christian Bentancur)

LT: Tristan Leigh (Brayden Jacobs)

LG: Collin Sadler OR Harris Sewell (Ronan O’Connell)

C: Ryan Linthicum (Harris Sewell)

RG: Walker Parks OR Elyjah Thurmon (Ronan O’Connell)

RT: Blake Miller (Mason Wade)

Defense

DE: Will Heldt OR Jahiem Lawson

DT: DeMonte Capehart OR Stephiylan Green (Amare Adams)

DT: Peter Woods OR Stephiylan Green (Vic Burley)

DE: T.J. Parker (Cade Denhoff)

MLB: Sammy Brown (Jeremiah Alexander OR Dee Crayton)

WLB: Wade Woodaz (Kobe McCloud OR Dee Crayton)

CB: Avieon Terrell (Branden Strozier)

Tiger (nickel): Misun Kelley (Corian Gipson OR Noah Dixon)

Rover (SS): Khalil Barnes OR Ronan Hanafin (Tyler Venables)

FS: Ricardo Jones (Kylon Griffin)

CB: Ashton Hampton OR Jeadyn Lukus (Corian Gipson)

Special teams

PK: Nolan Hauser (Robert Gunn III)

P: Jack Smith (Robert Gunn III OR Will McCune)

KO: Robert Gunn III

LS (PK): Holden Caspersen

LS (P): Philip Florenzo

H: Clay Swinney

PR: Antonio Williams

KOR: Adam Randall

This story was originally published October 31, 2025 at 8:00 AM.

Chapel Fowler
The State
Chapel Fowler, the NSMA’s 2024 South Carolina Sportswriter of the Year, has covered Clemson football and other topics for The State since summer 2022. His work’s also been honored by the Associated Press Sports Editors, the South Carolina Press Association and the North Carolina Press Association. He’s a Denver, N.C., native, a UNC-Chapel Hill alum and a pickup basketball enthusiast. Support my work with a digital subscription
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