Philadelphia Phillies at LA Dodgers odds, picks and predictions

The Philadelphia Phillies (29-27) open a 3-game series against the LA Dodgers (36-20) Friday with a 10:15 p.m. ET (Apple TV) first pitch from Dodger Stadium in Los Angeles, California. Let's analyze MLB odds around the Phillies vs. Dodgers odds and make our expert MLB picks and predictions for the best bets.

2025 season series: Phillies won 4-2

Philadelphia has won 3 games in a row after completing the sweep against the San Diego Padres with a 3-0 win Wednesday, covering as a -142 road favorite with the Under (7.0) hitting. SS Trea Turner had 2 RBIs, including a solo HR, while LHP Carlos Sanchez (7 IP, 6 H, 0 ER, 0 BB, 9 K) improved to 6-2.

Los Angeles has won 7 of its last 8 after completing the sweep against the Colorado Rockies Thursday with a 4-1 home victory as a -460 favorite with the Under (8.0) hitting. DH Shohei Ohtani and 1B Freddie Freeman both hit solo home runs in the first inning, while Ohtani did not allow a hit in his 6 innings on the mound (1 ER, 4 BB, 7 K). The Dodgers allowed just 1 hit in the victory.

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Phillies at Dodgers projected starters

RHP Zack Wheeler vs. LHP Justin Wrobleski

Wheeler (4-0, 1.67 ERA) makes his seventh start. He has a 0.82 WHIP, 1.9 BB/9 and 8.6 K/9 in 37 2/3 innings.

• Last start: Win, 6 IP, 2 H, 0 ER, 1 BB, 6 K in a 3-0 home victory vs. Cleveland Guardians Saturday
• Career vs. Dodgers: 3-2, 4.35 ERA (39 1/3 IP, 19 ER), 1.22 WHIP, 10.8 K/9 in 7 starts

Wrobleski (6-2, 3.07 ERA) makes his ninth start and 10th appearance. He has a 1.11 WHIP, 2.3 BB/9 and 5.0 K/9 in 55 2/3 innings.

• Last start: Loss, 5 IP, 5 ER, 8 H, 2 BB, 4 K in a 5-1 road loss against Milwaukee Brewers Friday
• Career vs. Phillies: 0-0, 135.00 ERA (1/3 IP, 5 ER), 15.00 WHIP, 0.0 K/9 in 1 appearance

Phillies at Dodgers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:05 a.m. ET.

• Moneyline (ML): Phillies +100 (bet $100 to win $100) | Dodgers -120 (bet $120 to win $100)
• Run line (RL)/Against the spread (ATS): Phillies -1.5 (+165) | Dodgers -1.5 (-200)
• Over/Under (O/U): 8.0 (O: -115 | U: -105)

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Phillies at Dodgers picks and predictions

Prediction

Phillies 4, Dodgers 3

Moneyline

BET PHILLIES (+100).

Wheeler has been nothing short of stellar for the Phillies this season, allowing just 7 ER with the Phillies winning all 6 of his starts. He provides an advantage to the visitors against a hot team. The Phillies have won 3 games in a row, allowing just 3 runs over that span. While it will be an uphill battle against one of the league's best teams, they dominated Wrobleski the only time they faced him, tacking on 5 runs while the youngster was only able to get a single out last Sept. 16.

Run line/Against the spread

PASS.

The moneyline has better value for the Phillies.

Over/Under

BET UNDER 8.0 (-105).

With Wheeler on the mound, who has a 1.67 ERA this season, the Dodgers' powerful offense will be on its heels. He has allowed 5 or fewer hits in 5 of his 6 starts this season, while going at least 6 innings in 5 of his 6 starts.

The Phillies have hit the under in 9 of their last 10. They have scored 4 or fewer runs in each of their last 8, while allowing 4 or fewer runs in 9 of their last 10, including 3 shutouts over their last 5 games.

The Dodgers have scored 4 or fewer runs in 4 of their last 9, while holding opponents to 4 or fewer in 9 of their last 10.

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This article originally appeared on Sportsbook Wire: Philadelphia Phillies at LA Dodgers odds, picks and predictions

Reporting by Seth Orlemann, Sportsbook Wire / Sportsbook Wire

USA TODAY Network via Reuters Connect

Copyright Reuters or USA Today Network via Reuters Connect

This story was originally published May 29, 2026 at 10:14 AM.