First look at South Carolina-LSU: Betting odds, TV details, more
South Carolina football returns from its bye week following the team’s first conference win against Kentucky. Now, the Gamecocks head to Baton Rouge, Louisiana for a matchup against the No. 11 LSU Tigers in Death Valley.
Here’s everything you need to know about USC’s road matchup:
How to watch South Carolina vs. LSU
When: 7:45 p.m. Saturday
Where: Tiger Stadium (Baton Rouge, La.)
TV/stream: SEC Network and the ESPN app
Series history: South Carolina is 2-18-1 against the Tigers. LSU won the last matchup 36-33 in Columbia during the 2024 season. USC’s last win came in 1994 in an 18-17 road victory.
Betting odds
USC is a 10-point underdog against LSU, according to the VegasInsider consensus line that factors in multiple sportsbooks. The over/under is 41.5 points.
About South Carolina
The Gamecocks are 3-2 on the year and 1-2 in the SEC. USC picked up its first conference win against Kentucky, 35-13, at home on Sept. 27. It marked the first time USC’s offense eclipsed 21 points and 150 rushing yards in SEC play this season. The upcoming matchup against LSU is the Gamecocks’ second SEC road game of the year.
About LSU
The Tigers, led by fourth-year head coach Brian Kelly, started off the year strong with a 4-0 record. LSU’s winning ways stopped Sept. 27 after a trip to Oxford, Mississippi ended in a 24-19 loss to Ole Miss. The Tigers will look to bounce back at home against USC before a stretch of three games against currently ranked opponents.
Players to watch: Gamecocks and Tigers
South Carolina
Matthew Fuller, RB: Fuller, a redshirt freshman, had a quiet start to the year before getting his first real shot against the Wildcats. He led the team in carries with 19 rushes for 48 yards and a touchdown. USC has struggled with the run in 2025, and may continue to lean on Fuller in an attempt to ignite its rushing offense.
Bryan Thomas Jr., edge rusher: The senior pass rusher had a career game against Kentucky, recording a career-high two sacks and seven tackles. He earned SEC Co-Defensive Player of the Week honors for his performance. LSU will likely put an immense effort toward stopping fellow edge rusher Dylan Stewart, which could leave lanes open for Thomas to disrupt the Tigers’ offense.
LSU
Garrett Nussmeier, QB: A Lake Charles, Louisiana product and a second-year starter for the Tigers, Nussmeier was tabbed as a potential Heisman candidate before the season. He’s completed 115 passes for 1,159 yards and seven touchdowns this year but has thrown three interceptions. He had his worst game of the season against the Rebels, finishing with 21 completions for 197 yards, a touchdown and a pick. He’ll be looking to bounce back against the Gamecocks.
Whit Weeks, LB: Weeks is a leader on the Tigers defense as a junior after a breakout year in 2024, where he finished with 120 tackles and 3.5 sacks. He’s had a slow start to 2025 but recorded a season-high 10 tackles against Ole Miss.
South Carolina 2025 football schedule
- Aug. 31: South Carolina 24, Virginia Tech 11
- Sept. 6: USC 38, SC State 10
- Sept. 13: Vanderbilt 31, USC 7
- Sept. 20: Missouri 29, USC 20
- Sept. 27: USC 35, Kentucky 13
- Oct. 11 at LSU, 7:45 p.m. ET (SEC Network)
- Oct. 18 vs. Oklahoma - TBD
- Oct. 25 vs. Alabama - TBD
- Nov. 1 at Ole Miss - TBD
- Nov. 15 at Texas A&M - TBD
- Nov. 22 vs. Coastal Carolina - TBD
- Nov. 29 vs. Clemson - Noon (ABC or ESPN)
This story was originally published October 6, 2025 at 7:00 AM.
