A.C. Flora at Orangeburg-Wilkinson: Flora looks to get offense going in region opener.

Pick: Orangeburg-Wilkinson

Airport at Midland Valley: This game decided region title last year. This year, both teams head into region opener struggling.

Pick: Airport

Batesburg-Leesville at Allendale-Fairfax: First meeting since 1996 between schools.

Pick: Batesburg-Leesville

Ben Lippen at Laurence Manning: Ben Lippen looks to stop two-game slide after hot start.

Pick: Ben Lippen

Blythewood at Dutch Fork: Winner has the upper hand in Region 5-5A race.

Pick: Dutch Fork

Broome at Mid-Carolina: Mid-Carolina gets QB Corey Stone back, but faces tough challenge.

Pick: Broome

C.A. Johnson at Fox Creek: Both teams carry losing streaks into region opener.

Pick: Fox Creek

Cardinal Newman at Pinewood Prep: Cardinal Newman has lost three in a row after 2-0 start.

Pick: Pinewood Prep

Chapin at Dreher: Region opener for both should have plenty of points.

Pick: Dreher

Columbia at Fairfield Central: Griffins will try to slow down Columbia RB Nate Miller.

Pick: Fairfield Central

Eau Claire at Saluda: Saluda Shrine Bowl back Malik Brooks is one of state’s best.

Pick: Saluda

Gray Collegiate at Keenan: Gray Collegiate averaging 265 yards a game through the air.

Pick: Gray Collegiate

Hammond at Augusta Christian: Hammond has scored 54 points in each of past two games.

Pick: Hammond

Lancaster at Westwood: Redhawks will try to bounce back after loss to No. 1 Dutch Fork.

Pick: Westwood

Lee Central at North Central: At 5-0, Lee Central has been one of state’s surprise teams.

Pick: Lee Central

Lexington at River Bluff: First two games decided by four points. This one might not be that close.

Pick: Lexington

Lower Richland at North Augusta: North Augusta is 0-2 against Midlands teams this year.

Pick: North Augusta

Lugoff-Elgin at Lakewood: Winless Lakewood averaging 6.5 points a game.

Pick: Lugoff-Elgin

Pelion at Brookland-Cayce: B-C averaging 400 yards a game on offense.

Pick: Brookland-Cayce

Richland Northeast at York: Even without Tyquandre Davis, RNE running game is clicking.

Pick: Richland Northeast

Ridge View at South Pointe: Statement game for Ridge View against two-time defending state champs.

Pick: Ridge View

Swansea at Gilbert: Gilbert coach Chad Leaphart faces former team.

Pick: Gilbert

White Knoll at Irmo: White Knoll has won four in a row after opening loss.

Pick: White Knoll

Wilson Hall at Heathwood Hall: Heathwood has scored 14 points or less in past four games.

Pick: Wilson Hall

Woodruff at Newberry: Newberry finally gets to play home game in renovated stadium.

Pick: Newberry

Last Week: 13-5

Season: 97-33

This story was originally published September 29, 2016 at 5:10 PM.