South Carolina Department of Public Safety officials said there were five road deaths reported over the weekend.
Officials said all of the deaths occurred on U.S. routes, S.C. roads and secondary roads.
In two of the deaths, officials said a seat belt was unknown. In the three other deaths, motorcyclists were killed.
As of Sunday, 408 people have died on state highways, compared to 409 highway deaths during the same time period in 2015. Of the 277 motor-vehicle occupants who have died in 2016, 131 were not wearing seat belts.
Forty-nine pedestrians have been killed compared to 47 during the same time period in 2015. Fifty-four motorcyclists have been killed compared to 56 this time in 2015. Ten bicyclists have died in 2016 compared to nine this time last year.