Clemson led Florida State by as many as 18 points in the second half before falling to the Seminoles 81-79 Wednesday night in Tallahassee.
The 11th-ranked Tigers (20-5, 9-4) were unable to overcome 21 turnovers and had their four-game winning streak snapped.
Clemson had multiple chances to tie the game in overtime after the Seminoles (18-8, 7-7) took the lead, but David Skara made only 1-of-2 free throws with the Tigers trailing by two with five seconds remaining.
Moments later, with Clemson down by three, Marcquise Reed was fouled and made the first free throw before missing the second on purpose. Elijah Thomas grabbed the rebound but was unable to convert under the basket.
Clemson led throughout regulation until FSU’s Trent Forrest tied the game on a layup with eight seconds remaining. The Seminoles ended regulation on a 6-0 run over the final two minutes to send the game to overtime.
The Tigers scored the first four points of overtime, all by Thomas, before Florida State rallied over the final two minutes.
CJ Walker nailed a 3-pointer with 1:56 remaining in overtime to cut Clemson’s lead to 74-73 before Forrest’s layup with 1:06 left gave FSU its first lead of the game.
Reed led all scorers with 23 points and added three rebounds and four assists.
Gabe DeVoe added 11 points, with Skara also finishing with 11 and Aamir Simms reaching double figures with 10 for the Tigers.
Phil Cofer led the Seminoles with 17 points, while Forrest added 16.
There was a scary moment late in the game as Clemson point guard Shelton Mitchell was hit in the head by a Florida State player while attempting a layup. Mitchell stayed down on the floor for several minutes before being carried off the floor.
The Tigers will next host No. 12 Duke Sunday at 1 p.m.